In vitro study on human tenocytes cultured with MD-TISSUE. The study demonstrated the production of new COL I and cell migration to the site of injury resulting in wound repair. Tissue inhibitor mRNA (TIMPS) levels of matrix metalloproteinases (MMPS) were assayed. Increased TIMPS modulated MMPS, reducing inflammatory processes and extracellular matrix degradation.
The study shows that MD-TISSUE acts as a mechanical scaffold capable of inducing an anabolic phenotype on human tenocytes, promoting tendon homeostasis and repair.
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