Prospective randomized study on 30 patients. The efficacy of collagen was compared across three infiltrative techniques (subcutaneous, periradicular, and epidural) in the treatment of low back pain (LBP) – lumbar spondylosis. The subcutaneous infiltration of MD-LUMBAR and MD-NEURAL was shown to be not inferior in terms of efficacy to periradicular and epidural infiltrations (evaluation with VAS scale and Oswestry).