COLLAGEN: WHAT IT IS, WHAT IT DOES

Collagen is the most abundant protein in the body (1) and it represents:

5-6% of adult human body weight ⁽¹⁾
30% of the total protein mass of higher animals ^(2,3)
90% of the body’s collagen is type I collagen ⁽⁴⁾
Location: skin, tendons, joint capsules, ligaments, cartilage, bones, muscles, teeth, extracellular matrix ^(1,3,4)

Properties: strength, rigidity, resistance, and flexibility ⁽⁵⁾

Collagen acts as a bio-scaffold that SUPPORTS, STRUCTURES and STABILISES the somatic scaffolding ⁽⁴⁾

^1. Ruiu DE. Advanced Therapies 2012; 1: 30-39
^2. Verzàr F. International Review of Connective Tissue Research 1964; 2: 243-300
^3. Martin Martin LS. et al. BMC Musculoskelet Disord 2016; 17: 94
^4. Milani L. Physiological Regulating Medicine 2019; 3-18
^5. Milani L. Physiological Regulating Medicine 2010; 3-15

COLLAGEN BIOSYNTHESIS DURING THE AGING PROCESS

In humans, collagen biosynthesis starts decreasing from 55-60 years of age

At a locomotor apparatus level, thinning and degeneration of cartilage surface appears, generating arthrosis, while tendon and ligament structureslose elasticity, which leads to and tendinosis and tendinopathies of various grade.

Biosynthesis of collagen, proteoglycans and elastin correlated to aging.

GUNA COLLAGEN MEDICAL DEVICES

Guna Collagen Medical Devices act as bio-scaffolds of the extracellular matrix.

They support tissue repair and regeneration processes when the connective component is degraded by overuse, ageing or injuries, which are frequently the cause of musculoskeletal pain. ⁽⁶⁾

Its effectivenessis due to the induction of endogenous collagen synthesis by fibroblasts.
Fibroblasts generate and exert force on the extracellular matrix during repair. These forces are expressedin the contraction of fibroblasts, which are essential for repairing damages. An optimal level of contractilecapacity of fibroblasts is necessary to facilitate repair processes and reduce scar formation. ⁽⁷⁾

Guna Collagen Medical Devices are Class III Medical Devices
^6. Randelli PS. GIOT 2010; 36: 211-222
^7. Massoud EIE. World J Orthop 2013; 4(4): 229–240

EFFECTS OF MD-TISSUE ON CULTURED HUMAN TENOCYTES: IN VITRO STUDY

The addition of MD-TISSUE to a culture of human tenocytes produces the following effects:

increased levels of type I collagen
stimulation of tenocyte migration for wound healing, mediated by a mechanical input
improvement of tenocyte binding to the extracellular matrix and of the ability to form more efficient focal adhesions to promote cell migration

MD-TISSUE, acting as a mechanical scaffold, could be an effective medical device to promote tendon healing in tendonitis with a regenerative and rehabilitative approach.

COLLAGEN: WHAT IT IS, WHAT IT DOES

COLLAGEN BIOSYNTHESIS DURING THE AGING PROCESS

GUNA COLLAGEN MEDICAL DEVICES

EFFECTS OF MD-TISSUE ON CULTURED HUMAN TENOCYTES: IN VITRO STUDY

Guna S.p.a.

ARE YOU AN ORTHOPEDIST/PHYSIATRIST/PAIN THERAPIST?

COLLAGEN: WHAT IT IS, WHAT IT DOES​

COLLAGEN BIOSYNTHESIS DURING THE AGING PROCESS

GUNA COLLAGEN MEDICAL DEVICES

EFFECTS OF MD-TISSUE ON CULTURED HUMAN TENOCYTES: IN VITRO STUDY

Guna S.p.a.

ARE YOU AN ORTHOPEDIST/PHYSIATRIST/PAIN THERAPIST?

COLLAGEN: WHAT IT IS, WHAT IT DOES