A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”). Martin Martin et al. BMC Musculoskelet Disord. 2016 Feb

Double-blind randomized controlled clinical study on 60 patients with 2nd-3rd degree knee OA. The study demonstrated the non-inferiority of MD-KNEE compared to hyaluronic acid (Supartz). The Lequesne Index (LKI) and VAS scale were used for pain assessment.